The draft curriculum (still evolving):
1. Curriculum Aims, Goals, and Objectives
- Aim: To provide a comprehensive understanding of the pharmaceutical pathway from molecule to drug, emphasizing the importance of interdisciplinary collaboration and ethical considerations in the drug development process.
- Goals: Equip learners with the knowledge, skills, and competencies necessary to effectively contribute to various stages of drug development.
- Objectives: Organized according to Bloom’s taxonomy, ranging from basic knowledge and understanding to the ability to apply, analyze, evaluate, and create within the context of the pharmaceutical pathway.
2. Content
- Detailed exploration of the main steps of the pharmaceutical pathway, key terms, and concepts.
- Overview of bioinformatics tools, databases, and their applications in drug development.
- Case studies highlighting the role of interdisciplinary collaboration and regulatory considerations.
3. Learning Experiences
- Interactive modules and simulations for applying bioinformatics tools in drug candidate research.
- Group projects and presentations to demonstrate the pathway of a drug from molecule to drug, incorporating interdisciplinary perspectives.
- Case study analyses to understand the complexities and challenges of drug development.
4. Teaching Strategies
- Use of diverse didactical approaches tailored to different learning objectives, such as lecture-based learning for knowledge acquisition, problem-based learning for application and analysis, blended learning with online video lectures, and project-based learning for evaluation and creation activities.
- Incorporation of guest lectures from industry professionals to provide real-world insights and reinforce the importance of interdisciplinary collaboration.
5. Assessment and Evaluation
- Quizzes and exams to assess knowledge and understanding of drug development steps and key terms.
- Practical assignments using bioinformatics tools to apply theoretical knowledge.
- Group projects evaluating the impact of regulatory and ethical considerations, and the effectiveness of interdisciplinary collaboration.
6. Resources
- Access to bioinformatics databases and software for practical exercises.
- Recommended readings and online resources covering each step of the drug development pathway, interdisciplinary collaboration, and ethical considerations.
7. Implementation Plan
- A structured timeline that progressively builds from foundational knowledge to more complex analysis and creative problem-solving.
- Allocation of modules or units corresponding to each domain of Bloom’s taxonomy, ensuring a logical progression that facilitates deep learning.
8. Feedback and Revision
- Regular formative feedback mechanisms through quizzes, instructor feedback on assignments, and peer reviews.
- Summative feedback at the end of the course through course evaluations and reflection essays to assess how well the learning objectives were met and identify areas for improvement.
The table below integrates the curriculum elements of the face to face module and additional project outputs.
Face-to-face Course Modules | Slidesets | Supporting Materials | QR Book chapter | Lab guide | Ecourse module | |
---|---|---|---|---|---|---|
DAY 1 | ||||||
08:30-09:00 | Opening-Registration-Pretest | |||||
09:00-09:50 | Introduction and icebreaking | |||||
10:00-10:50 | Discovery 1: Molecules | 20-30 slides | 2 D modelling game | Yes | Scenario | Yes |
11:00-11:50 | Discovery 2: Bioinformatics | 20-30 slides | sample applications | Yes | Yes | |
12:00-12:50 | Lunch Break | Yes | ||||
13:00-13:50 | Research 1: Preclinical drug studies | 20-30 slides | 3 D modelling game | Yes | Yes | |
14:00-14:30 | Research 2: Cell culture, Xcelligence analysis | 20-30 slides | Video/Application | Yes | Lab guide (SOP format) | Yes |
14:30-15:10 | Research 3 - Recombinant Protein Production, Purification And Characterization | 20-30 slides | Video/Application | Yes | Lab guide (SOP format) | Yes |
15:10-16:10 | Research 4 - Bioinformatics & Pharmaco-Genomics | 20-30 slides | sample applications | Yes | Lab guide (SOP format) | Yes |
16:10-16:50 | Research 5 - Nanoparticles, drug release | 20-30 slides | Video/Candidate nanoparticle models with 3D printing | Yes | Lab guide (SOP format) | Yes |
16:50-17:10 | Research 6 - In vivo tests and GLP | 20-30 slides | Video/Application | Yes | Lab guide (SOP format) | Yes |
17:10-17:50 | Debrief of day 1 | |||||
Day 2 | ||||||
08:30-09:00 | Synthesis of the Day 1 | |||||
09:00-09:50 | Development (Clinical trials and GCP) | 20-30 slides | Video/Application | Yes | Yes | |
10:00-10:50 | Registration (Technical requirements, Pharmacopea, Licencing and Patenting) | 20-30 slides | Sample of CTD file | Yes | Yes | |
11:00-11:50 | Manufacturing and Quality (Lab Safety, GMP) | 20-30 slides | Video/Application | Yes | Yes | |
12:00-12:50 | Lunch Break | Yes | ||||
13:00-13:50 | Delivery (Compliance, delivery, pharmocovigilens, survey) | 20-30 slides | Video/Application | Yes | Yes | |
14:00-14:50 | Case study: Thalidomid Disaster | 10-15 slides | Video/(Talidomide and comic book) | |||
15:00-15:50 | Post test, evaluation, project outputs | |||||
16:00-16:50 | Closing and certification |